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US20090269281 |
Calcium/Calmodulin-Dependent Protein Kinase Kinase as a Control Point for Cardiac Hypertrophy
The present invention includes compositions and methods for treating a patient with cardiac hypertrophy by providing the patient with an effective amount of a Calmodulin kinase kinase inhibitor...
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7605259 |
Structurally rigid dopamine d3 receptor selective ligands and process for making them
A family of structurally rigid dopamine D3 receptor selective ligands is described. The family of structurally rigid dopamine D3 receptor selective ligands has the formula wherein A is cis or trans...
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US20090218516 |
Ratiometric Surface Plasmon Coupled Emission Detector
The present invention includes methods for ratiometric detection of analytes by surface plasmon coupled emission detection that includes disposing a target on the metal layer of a surface plasmon...
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7572781 |
Prodrugs for use as ophthalmic agents
The subject invention provides a mechanism by which steroidal quinol compounds confer beneficial ophthalmic effects. The subject compounds possess a lipophilic-hydrophilic balance for transcorneal...
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US20090156637 |
BUTYROPHENONES AND SIGMA-1 RECEPTOR ANTAGONISTS PROTECT AGAINST OXIDATIVE-STRESS
The present invention includes compositions and methods for the protection of one or more central nervous system cells from trauma, when administered before, during or after the trauma, wherein the...
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7534779 |
Quinol compound and pharmaceutical composition
The subject invention provides a mechanism by which steroidal quinol compounds confer beneficial ophthalmic effects. The subject compounds possess a lipophilic-hydrophilic balance for transcorneal...
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US20090110739 |
Targeted cancer chemotherapy using synthetic nanoparticles
Compositions and methods for delivery of a pharmaceutical to an individual. Delivery vehicles are provided in a formulation of a pharmaceutical that is encapsulated in a synthetic self assembled...
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7524622 |
Methods for increasing production of IFN-gamma in natural killer cells expressing LLT1 receptor
Natural killer (NK) cells possess the inherent capacity to kill various tumor and virally infected cells. A large family of NK cell receptors belongs to the C-type lectin super-family. Genes in the...
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US20090075888 |
Cardiovascular and Brain Cell Therapy Using Intracellular Ryanodine Receptor Modulation by the Estrogen Receptor Beta
The present invention includes compositions and methods for screening for a candidate substance with ryanodine receptor (RyR)-modulatory activity, the method including: determining the...
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US20080253961 |
Formulation of Active Agent Loaded Activated PLGA Nanoparticles for Targeted Cancer Nano-Therapeutics
The present invention includes compositions and methods of making an activated polymeric nanoparticle for targeted drug delivery that includes a biocompatible polymer and an amphiphilic stabilizing...
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US20080231834 |
SURFACE PLASMON ASSISTED MICROSCOPE
The present invention includes a microscope and a method for using the microscope for single molecule with reduced photobleaching of a fluorophore ( 20 ) that includes a light translucent material...
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US20080193915 |
Isotope Labeled Dinitrophenylhydrazines and Methods of Use
The subject invention provides novel isotope-labeled dinitrophenylhydrazines (DNPHs) and methods for their use in detecting and/or quantifying carbonyl groups in proteins and other analytes. In...
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7405192 |
Bone morphogenic proteins (BMP), BMP receptors and BMP binding proteins and their use in the diagnosis and treatment of glaucoma
The present invention provides methods and kits for diagnosing and treating glaucoma.
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US20080085882 |
Compositions and Methods for Potentiation of Cancer Agents
The present invention includes compositions and method to improve the therapeutic index of anti-cancer agents using a novel anti-cancer agent and a modulator or potentiator thereof.
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US20080045419 |
Screening Assay
The present invention includes a system and methods for the detection, isolation and characterization of candidate agents in a functional screening assay in agarose.
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7300926 |
Steroidal quinols and their use for estrogen replacement therapy
The present invention relates to novel estrogen-related steroidal quinols and their use as drugs for estrogen replacement therapy. The quinols of the present invention provide improved...
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US20070141581 |
Membrane androgen receptor as a therapeutic target for the prevention/promotion of cell death
The present invention includes compositions, kits and methods for specifically and differentially activating a membrane androgen receptor and their use for comparing the binding specificity of one...
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US20070129611 |
System, Method and Apparatus for Assessing Menopausal or Post-Hysterectomy Symptoms
The present invention provides a system, method and apparatus for assessing a person's menopausal or post-hysterectomy symptoms by providing a first set and a second set of questions to the person,...
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US20070129441 |
PROTECTION OF CELLS FROM ADVERSE EXTERNAL OR INTRINSIC EFFECTS, CELLULAR DEGENERATION AND DEATH BY N-ACYLETHANOLAMINES
The present invention includes compositions and methods for treating diseases of the eye and skin by modulating the amount of intracellular calcium using transdermal or transcorneal delivery of one...
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US20060142395 |
Modulation of intracellular calcium signaling by N-acylethanolamines
The present invention includes compositions and methods for neuroprotection by modulating intracellular calcium concentrations by administering an effective amount of an N-acylethanolamine to a...
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US20060111388 |
Phenanthroline and derivatives thereof used to lower intraocular pressure in an affected eye
Methods and compositions used for lowering intraocular pressure. More particularly, the methods and compositions for lowering intraocular pressure pertain to the use of at least a phenanthroline...
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US20060106064 |
Butyrophenones and sigma-1 receptor antagonists protect against oxidative-stress
The present invention includes compositions and methods for the protection of one or more central nervous system cells from trauma, when administered before, during or after the trauma, wherein the...
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US20060002892 |
LLT uses thereof in immune system modulation
Natural killer (NK) cells possess the inherent capacity to kill various tumor and virally infected cells and mediate the rejection of bone-marrow grafts in lethally irradiated animals. A large...
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US20050130878 |
Prevention of photic injury by administering a TACE inhibitor
The present invention relates to is directed to methods of preventing neurodegeneration resulting from photo-oxidative stress. The methods of the invention involve inhibiting the action of the...
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US20040224995 |
Neuroprotective effects of PPARy agonists against cellular oxidative insults
The current invention comprises compositions and methods for protecting a neuronal cell of a subject from a toxic insult. The method includes delivering an effective amount of a neuroprotective...
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US20030176356 |
Endothelin antagonists and endothelin-converting enzyme inhibitors for the treatment of glaucoma
A pharmaceutical composition, containing a therapeutically effective amount of an endothelin (“ET”) antagonists and/or an endothelin-converting enzyme (“ECE”) inhibitors and a...
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US20030113332 |
Immuno activation of CS1 receptor in natural killer cells to inhibit tumor cell growth
The present invention relates to nucleic acid molecules encoding cell surface receptors on immune cells and the characteristic peptides that comprise these receptors. More specifically, the present...
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